GSE86116 The role of ASAH1 in melanoma progression

Contributors : Parmanand Malvi ; Narendra WajapeyeeSeries Type : Expression profiling by arrayOrganism : Homo sapiensAcid ceramidase (ASAH1) has been shown to be important for progression of several tumors. ASAH1 expression is elevated in multiple cancer types including cutaneous melanoma. Therefore, we analyzed the role of ASAH1 in melanoma. Inhibition of ASAH1 in melanoma cell lines resulted in decreased proliferation, and increased cell death. ASAH1 expression is regulated through MAP kinase pathway and inhibition of MAPK pathway leads to diminished ASAH1 expression.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research