Maharashtra reports first case of Zika virus from a village in Pune

Source: The Economic Times - Category: Consumer Health News Source Type: news

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Speaker Alexandra L. Phelan is an Adjunct Professor in Global and Public Health Law and Ethics, Doctor of Juridical Science (SJD) candidate and General Sir John Monash Scholar at Georgetown University in Washington DC. Professor Phelan ’ s doctoral research examines the global governance of infectious diseases, with a focus on Australian, Chinese and US laws relating to the health and human rights of vulnerable population groups. Professor Phelan ’ s research explores the key legal issues of emerging and re-emerging infectious diseases – such as Ebola, Pandemic Influenza, MERS, and Zika Virus – in t...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
The Germantown company develops tests for what it calls “neglected infectious diseases” like Ebola and Zika virus.
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news
Biomed Res Int. 2021 Sep 8;2021:9989478. doi: 10.1155/2021/9989478. eCollection 2021.ABSTRACTINTRODUCTION: Recent experiences from global outbreaks have highlighted the severe disruptions in sexual and reproductive health services that expose women and girls to preventable health risks. Yet, to date, there is no review studying the possible impact of outbreaks on sexual and reproductive health (SRH). Methodology. Studies reporting outbreaks impacting sexual and reproductive health and pregnancy outcomes were identified using MEDLINE, Embase, and ISI-WoS. Reported impacts were reviewed at systems, community, and legislative...
Source: Biomed Res - Category: Research Authors: Source Type: research
immons Andres Mejia Kathleen M. Antony Terry Morgan Saverio Capuano III Mary L. Schneider Matthew T. Aliota Thomas C. Friedrich David H. O’Connor Thaddeus G. Golos Emma L. Mohr Infants exposed to Zika virus (ZIKV) prenatally may develop birth defects, developmental deficits, or remain asymptomatic. It is unclear why some infants are more affected than others, although enhancement of maternal ZIKV infection via immunity to an antigenically similar virus, dengue virus (DENV), may play a role. We hypothesized that DENV immunity may worsen prenatal ZIKV infection and developmental deficits in offs...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
INTRODUCTION
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Zika virus (ZIKV) infection has been associated with a series of neurological pathologies. In patients with ZIKV-induced neurological disorders, the virus is detectable in the central nervous system. Thus, ZIKV is capable of neuroinvasion, presumably through infection of the endothelial cells that constitute the blood-brain barrier (BBB). We demonstrate that susceptibility of BBB endothelial cells to ZIKV infection is modulated by the expression of tight-junction protein claudin-7 (CLDN7). Downregulation of CLDN7 reduced viral RNA yield, viral protein production, and release of infectious viral particles in several endothe...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In this study, we aimed to explore the role of MxA in ZIKV infection and its potential mechanisms. MxA overexpression was achieved by transfection with plasmid. The levels of MxA expression and ZIKV replication were assayed by both qRT-PCR and western blot. The activation status of Jak/STAT signaling pathway was evaluated at three levels: phosphorylation of STAT1 and STAT2(p-STAT1, p-STAT2) (western blot), activity of interferon sensitive response element (ISRE) (dual luciferase reporter gene assay), and the expression levels of ISGs (qRT-PCR). Our results showed that MxA overexpression inhibited ZIKV replication with no e...
Source: Virus Research - Category: Virology Authors: Source Type: research
J Mol Biol. 2021 Sep 16:167249. doi: 10.1016/j.jmb.2021.167249. Online ahead of print.ABSTRACTIn the past decade, emerging virus outbreaks like SARS-CoV-2, Zika and Ebola have presented major challenges to the global health system. Viruses are unique pathogens in that they fully rely on the host cell to complete their lifecycle and potentiate disease. Therefore, programmed cell death (PCD), a key component of the host innate immune response, is an effective strategy for the host cell to curb viral spread. The most well-established PCD pathways, pyroptosis, apoptosis and necroptosis, can be activated in response to viruses....
Source: Mol Biol Cell - Category: Molecular Biology Authors: Source Type: research
In this study, we aimed to explore the role of MxA in ZIKV infection and its potential mechanisms. MxA overexpression was achieved by transfection with plasmid. The levels of MxA expression and ZIKV replication were assayed by both qRT-PCR and western blot. The activation status of Jak/STAT signaling pathway was evaluated at three levels: phosphorylation of STAT1 and STAT2(p-STAT1, p-STAT2) (western blot), activity of interferon sensitive response element (ISRE) (dual luciferase reporter gene assay), and the expression levels of ISGs (qRT-PCR). Our results showed that MxA overexpression inhibited ZIKV replication with no e...
Source: Virus Research - Category: Virology Authors: Source Type: research
Purpose of review Due to the impact of the COVID-19 pandemic this past year, we have witnessed a significant acceleration in the science, technology, and policy of global health security. This review highlights important progress made toward the mitigation of Zika, Ebola, and COVID-19 outbreaks. These epidemics and their shared features suggest a unified policy and technology agenda that could broadly improve global health security. Recent findings Molecular epidemiology is not yet in widespread use, but shows promise toward informing on-the-ground decision-making during outbreaks. Point-of-care (POC) diagnostic...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: TROPICAL AND TRAVEL-ASSOCIATED DISEASES: Edited by Christina M. Coyle Source Type: research
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