Standardized Aronia melanocarpa extract regulates redox status in patients receiving hemodialysis with anemia

Mol Cell Biochem. 2021 Jul 29. doi: 10.1007/s11010-021-04225-y. Online ahead of print.ABSTRACTThe aim of our study was to investigate the effects of one-month consumption of polyphenol-rich standardized Aronia melanocarpa extract (SAE) on redox status in anemic hemodialysis patients. The study included 30 patients (Hb 3 months;> 3 times week). Patients were treated with commercially available SAE in a dose of 30 ml/day, for 30 days. After finishing the treatment blood samples were taken to evaluate the effects of SAE on redox status. Several parameters of anemia and inflammation were also followed. After the completion of the treatment, the levels of superoxide anion radical and nitrites significantly dropped, while the antioxidant capacity improved via elevation of catalase and reduced glutathione. Proven antioxidant effect was followed by beneficial effects on anemia parameters (increased hemoglobin and haptoglobin concentration, decreased ferritin and lactate dehydrogenase concentration), but SAE consumption didn't improve inflammatory status, except for minor decrease in C-reactive protein. The consumption of SAE regulates redox status (reduce the productions of pro-oxidative molecules and increase antioxidant defense) and has beneficial effects on anemia parameters. SAE could be considered as supportive therapy in patients receiving hemodialysis which are prone to oxidative stress caused by both chronic kidney disease and hemodialysis procedure. Additionally, it could...
Source: Molecular and Cellular Biochemistry - Category: Biochemistry Authors: Source Type: research

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Curr Drug Saf. 2021 Nov 22. doi: 10.2174/1568009621666211123095129. Online ahead of print.ABSTRACTBACKGROUND: Anemia is one of the most common complications of Chronic Kidney Disease (CKD). The vast majority of Egyptian CKD patients are interchangeably treated with Darbepoetin Alfa (DPA) and Epoetin Alfa (EPA) to achieve and maintain target hemoglobin levels. Our study aimed to compare the efficacy and safety of DPA versus EPA for managing anemia amongst Egyptian patients with CKD undergoing dialysis.METHODS: A multicenter, open label, randomized, prospective, parallel study was conducted. Patients with CKD undergoing dialysis with Hb level
Source: Current Drug Safety - Category: Drugs & Pharmacology Authors: Source Type: research
AbstractAimsWhereas the combination of anaemia and chronic kidney disease (CKD) has been extensively studied in patients with heart failure (HF), the contribution of iron deficiency (ID) to this dysfunctional interplay is unknown; we aimed to assess clinical associates and pathophysiological pathways related to ID in this multimorbid syndrome.Methods and resultsWe studied 2151 patients with HF from the BIOSTAT-CHF cohort. Patients were stratified based on ID (TSAT
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Research Article Source Type: research
Ferric citrate is approved as an iron replacement product in patients with non-dialysis chronic kidney disease and iron deficiency anemia. Ferric citrate-delivered iron is enterally absorbed, but the specific mechanisms involved have not been evaluated, including the possibilities of conventional, transcellular ferroportin-mediated absorption and/or citrate-mediated paracellular absorption. Here, we first demonstrate the efficacy of ferric citrate in high hepcidin models, including Tmprss6 knockout mice (characterized by iron-refractory iron deficiency anemia) with and without adenine diet-induced chronic kidney disease.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: basic research Source Type: research
Curr Protein Pept Sci. 2021 Nov 21. doi: 10.2174/1389203722666211122092309. Online ahead of print.ABSTRACTExposure to organophosphorus pesticides is an important public health issue due to a large number of occupationally exposed populations, as well as their effects mainly at the level of the nervous, reproductive, and immune systems. It has been reported that one of the molecular mechanisms by which adverse effects of exposure to organophosphorus pesticides can be explained is oxidative stress, which leads to alterations at the cellular level that, if chronic, could affect the functionality of different organs and tissue...
Source: Current Protein and Peptide Science - Category: Biochemistry Authors: Source Type: research
The most important contributors to the anemia of patients with chronic kidney disease are insufficient erythropoietin production and erythropoietin hyporesponsiveness, decreased red blood cell half-life, iron deficiency, and inflammation. However, in contrast to the role of kidney failure, that of proteinuria and nephrotic syndrome is less clear. Bissinger et  al. now provide evidence in mouse models and patients with chronic kidney disease that heavy proteinuria alters erythrocyte metabolism and increases erythrocyte death.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
ConclusionsA diverse cohort of children with CKD has a narrow and homogeneous intake of vegetable protein. Due to the low variability of plant-based protein in the cohort, there were no associations between the percentage of plant protein intake and changes in eGFR nor electrolyte balance.A higher resolution version of the Graphical abstract is available asSupplementary information
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
This study explored the association between metabolic parameters with anemia and electrolyte and mineral disorders amon...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Research Source Type: research
CONCLUSION: Pegylated erythropoietin is better than darbepoetin alfa in overcoming erythropoietin hyporesponsiveness and maintaining stable hemoglobin levels in CKD patients on maintenance hemodialysis.PMID:34781656
Source: Journal of the Association of Physicians of India - Category: General Medicine Authors: Source Type: research
Conclusion: PAH is an important complication in CKD and its severity increases with deterioration of renal function in CKD. Various risk factors are present and treatment of these can decrease the progress and severity of PAH, thereby decreasing the morbidity and mortality in CKD.PMID:34781651
Source: Journal of the Association of Physicians of India - Category: General Medicine Authors: Source Type: research
CONCLUSION: Pegylated erythropoietin is better than darbepoetin alfa in overcoming erythropoietin hyporesponsiveness and maintaining stable hemoglobin levels in CKD patients on maintenance hemodialysis.PMID:34781656
Source: Journal of the Association of Physicians of India - Category: General Medicine Authors: Source Type: research
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