Assessing the added value of GBS maternal immunisation in preventing maternal infection and foetal harm: population surveillance study

BJOG. 2021 Jul 29. doi: 10.1111/1471-0528.16852. Online ahead of print.ABSTRACTOBJECTIVE: To assess the incidence of maternal group B streptococcal (GBS) infection in England DESIGN: Population surveillance augmented through data linkage.SETTING: England POPULATION: All pregnant women accessing the National Health Service (NHS) in England METHODS: Invasive GBS (iGBS) infections during pregnancy or within six weeks of childbirth were identified by linking Public Health England (PHE) national microbiology surveillance data for 2014 to NHS hospital admission records. Capsular serotypes of GBS were determined by reference laboratory typing of clinical isolates from women aged 15-44y. Post-caesarean section surgical site infection (SSI) caused by GBS was identified in 21 hospitals participating in PHE SSI surveillance (2009-15).MAIN OUTCOME MEASURES: iGBS rate per 1000 maternities; risk of GBS SSI per 1000 C-sections.RESULTS: Of 1601 patients diagnosed with iGBS infections in England in 2014, 185 (12%) were identified as maternal infections, 0.29 (95% CI 0.25-0.33) per 1000 maternities, 83% of all iGBS cases in women 18-44y. Seven (3.8%) were associated with miscarriage. Foetal outcome identified excess rates of stillbirth (3.4% vs 0.5%) and extreme prematurity (
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Source Type: research

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ConclusionFor women with POR, the clinical outcome of the hMG + DYG group was similar to that of the hMG + MPA group, indicating that both combinations can be useful options for PPOS protocols.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
AbstractPurposeComparative analysis of multilocus imprinting disturbances (MLIDs) in miscarriages from women with sporadic (SPL) and recurrent pregnancy loss (RPL) and identification of variants in the imprinting control geneNLRP7 that may lead to MLIDs.MethodsChorionic cytotrophoblast and extraembryonic mesoderm samples from first-trimester miscarriages were evaluated in 120 women with RPL and 134 women with SPL; 100 induced abortions were analyzed as a control group. All miscarriages had a normal karyotype. Epimutations in 7 imprinted genes were detected using methyl-specific PCR and confirmed with DNA pyrosequencing. Se...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
ConclusionOur observation suggests that mild stimulation with letrozole could produce similar pregnancy outcomes in ovulatory patients who undergo FET when compared with a natural cycle.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
BackgroundWith the development of embryo freezing and warming technology, frozen-thawed embryo transfer (FET) has been widely utilized. However, studies investigating the association between cryopreservation duration and FET outcomes are limited and controversial, and previous studies did not conduct stratification analyses based on demographic or clinical characteristics.MethodsThis multicenter retrospective study included 17,826 women who underwent their first FET following the freeze-all strategy during the period from January 2014 to December 2018. Duration of cryopreservation was categorized into five groups: 3–...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Exp Ther Med. 2021 Nov;22(5):1232. doi: 10.3892/etm.2021.10666. Epub 2021 Aug 31.ABSTRACTα-Lipoic acid (ALA) is a natural molecule that is inconsistently synthesized by the human body and must be provided from exogenous sources, such as food and dietary supplements. Once absorbed, the oxidized form of ALA is transformed into its reduced form, dihydrolipoic acid (DHLA). ALA/DHLA exert direct and indirect antioxidant, anti-inflammatory and fine immunomodulatory effects. ALA/DHLA reduce the levels of pro-inflammatory cytokines (IL-1β, IL-6, IL-8 and IL-17), while increasing the secretion of anti-inflammatory cytoki...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Authors: Source Type: research
Ann Med Surg (Lond). 2021 Sep 8;70:102833. doi: 10.1016/j.amsu.2021.102833. eCollection 2021 Oct.ABSTRACTVitiligo is one of the dermatomes affecting the melanocytes resulting in their destruction and subsequent patchy depigmentation of the skin. It is postulated to occur due to an autoimmune problem. Despite being a disease with limited systemic involvement and lack of mortality, it has a severe psychological impact. It may have a powerfully negative effect on a patient's quality of life. The relationship between vitiligo and pregnancy is not widely acknowledged. It may be associated with adverse pregnancy outcomes such as...
Source: Annals of Medicine - Category: Internal Medicine Authors: Source Type: research
Exp Ther Med. 2021 Nov;22(5):1232. doi: 10.3892/etm.2021.10666. Epub 2021 Aug 31.ABSTRACTα-Lipoic acid (ALA) is a natural molecule that is inconsistently synthesized by the human body and must be provided from exogenous sources, such as food and dietary supplements. Once absorbed, the oxidized form of ALA is transformed into its reduced form, dihydrolipoic acid (DHLA). ALA/DHLA exert direct and indirect antioxidant, anti-inflammatory and fine immunomodulatory effects. ALA/DHLA reduce the levels of pro-inflammatory cytokines (IL-1β, IL-6, IL-8 and IL-17), while increasing the secretion of anti-inflammatory cytoki...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Authors: Source Type: research
In conclusion, Dupilumab use appears safe during gestation. Further studies are needed, especially to better understand the mechanisms underlying the pharmacological actions and ADR of Dupilumab.PMID:34533820 | DOI:10.26355/eurrev_202109_26652
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Authors: Source Type: research
Clin Mol Hepatol. 2021 Sep 17. doi: 10.3350/cmh.2021.0205. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Maternal and fetal outcomes in pregnant patients with NAFLD have been largely unexplored. To determine the level of evidence associated with both maternal and fetal outcomes in pregnant women with NAFLD.METHOD: We conducted a comprehensive literature search. The studies included pregnant patients with a previous, current or subsequent diagnosis of NAFLD. We used a random-effects model using odds ratios (OR) with 95% confidence intervals (CI).RESULTS: Twenty two studies, with 13641 female NAFLD patients were reviewe...
Source: Clinical and molecular hepatology - Category: Gastroenterology Authors: Source Type: research
In conclusion, Dupilumab use appears safe during gestation. Further studies are needed, especially to better understand the mechanisms underlying the pharmacological actions and ADR of Dupilumab.PMID:34533820 | DOI:10.26355/eurrev_202109_26652
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Source Type: research
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