Optimising the energetic cost of the glutamatergic synapse

This article will review how much of the energetic cost of the brain reflects the activity of glutamatergic synapses, consider the relative amount of energy used pre- and postsynaptically, outline how evolution has energetically optimised synapse function by adjusting the presynaptic release probability and the postsynaptic number of glutamate receptors, and speculate on how energy use by synapses may be sensed and adjusted.PMID:34314736 | DOI:10.1016/j.neuropharm.2021.108727
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research