Hyperimmune Globulin Does Not Prevent Congenital CMV Infection

FRIDAY, July 30, 2021 -- Administration of cytomegalovirus (CMV) hyperimmune globulin versus placebo to women with primary CMV infection in early pregnancy does not result in a lower incidence of congenital CMV infection or perinatal death in their...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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Hayes K, Gibas H. Placental cytomegalovirus infection without fetal involvement following primary infection in pregnancy. J  Pediatr 1971;79:401-5.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Source Type: research
Congenital cytomegalovirus (CMV) is the most common congenital infection globally, however information about CMV is not routinely included in antenatal education in the United Kingdom. This feasibility study a...
Source: BMC Pregnancy and Childbirth - Category: OBGYN Authors: Tags: Research article Source Type: research
Biochim Biophys Acta Mol Basis Dis. 2021 Jul 31:166231. doi: 10.1016/j.bbadis.2021.166231. Online ahead of print.ABSTRACTOther than being a physiological process, pregnancy is a condition characterized by major adaptations of maternal endocrine and metabolic homeostasis that are necessary to accommodate the fetoplacental unit. Unfortunately, all these systemic, cellular, and molecular changes in maternal physiology also make the mother and the fetus more prone to adverse outcomes, including numerous alterations arising from viral infections. Common infections during pregnancy that have long been recognized as congenitally ...
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Source Type: research
We report the first case of hemophagocytic syndrome, which occurred in a pregnantfemale patient 14 years after kidney transplant who displayed an atypical presentation and who had septic shock following cytomegalovirus infection. The patient, a-39-year-old woman at 27 weeks gestation with end-stage renal disease of unknown etiology, was admitted 14 years after living-donor kidney transplant (donor was her father) with high-grade fever, cough, and pancytopenia. Her immunosuppressant regimen included tacrolimus, azathioprine, and prednisone. Initially, she was hospitalized in the intensive care unit for septic shock without ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Source Type: research
Pregnancy is an immunological paradox whereby maternal immunity accepts a genetically unique fetus (or fetuses), while maintaining protective innate and adaptive responses to infectious pathogens. This close contact between the genetically diverse mother and fetus requires numerous mechanisms of immune tolerance initiated by trophoblast cell signals. However, in a placental condition known as villitis of unknown etiology (VUE), there appears to be a breakdown in this tolerance allowing maternal cytotoxic T-cells to traffic into the placenta to destroy fetal villi. VUE is associated with several gestational complications an...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Journal of Perinatology, Published online: 20 July 2021; doi:10.1038/s41372-021-01157-9Primary cytomegalovirus infection during pregnancy and congenital infection: a population-based, mother–child, prospective cohort study
Source: Journal of Perinatology - Category: Perinatology & Neonatology Authors: Source Type: research
A wide array of pathogens has the potential to injure the fetus and induce teratogenesis, the process by which mutations in fetal somatic cells lead to congenital malformations. Rubella virus was the first infectious disease to be linked to congenital malformations due to an infection in pregnancy, which can include congenital cataracts, microcephaly, hearing impairment and congenital heart disease. Currently, human cytomegalovirus (HCMV) is the leading infectious cause of congenital malformations globally, affecting 1 in every 200 infants. However, our knowledge of teratogenic viruses and pathogens is far from complete. N...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
In this study, guinea pig cytomegalovirus (GPCMV) was used to model primary maternal infection and compare the effects of infection at two different times on the placenta. When guinea pigs were infected with GPCMV at either 21- or 35-days gestation (dGA), maternal and placental viral loads, as determined by droplet digital PCR, were not significantly affected by the timing of maternal infection. However, when the transcriptomes of gestational age-matched GPCMV-infected and control placentas were compared, significant infection-associated changes in gene expression were only observed after maternal infection at 35 dGA. Nota...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Biochim Biophys Acta Mol Basis Dis. 2021 Jun 9:166198. doi: 10.1016/j.bbadis.2021.166198. Online ahead of print.ABSTRACTSome maternal infections, contracted before or during pregnancy, can be transmitted to the fetus, during gestation (congenital infection), during labor and childbirth (perinatal infection) and through breastfeeding (postnatal infection). The agents responsible for these infections can be viruses, bacteria, protozoa, fungi. Among the viruses most frequently responsible for congenital infections are Cytomegalovirus (CMV), Herpes simplex 1-2, Herpes virus 6, Varicella zoster. Moreover Hepatitis B and C virus...
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Source Type: research
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