Location of Gastrointestinal Stromal Tumor (GIST) in the Stomach Predicts Tumor Mutation Profile and Drug Sensitivity

CONCLUSIONS: We provide the first evidence that the mutational landscape of gastric GIST is related to tumor location. Proximal gastric GIST are overwhelmingly KIT mutant, irrespective of morphology or age, while distal tumors display non-KIT genomic diversity. Anatomic location of gastric GIST may therefore provide immediate guidance for clinical treatment decisions and selective confirmatory genomic testing when resources are limited.PMID:34326133 | DOI:10.1158/1078-0432.CCR-21-1221

Source: Clinical Cancer Research - July 30, 2021 Category: Cancer & Oncology Authors: Ashwyn K Sharma Jorge De la Torre Nikki S IJzerman Thomas L Sutton Beiqun Zhao Tahsin M Khan Sudeep Banerjee Christina Cui Vi Nguyen Maha Alkhuziem Petur Snaebjornsson Hester Van Boven Annemarie Bruining Chih-Min Tang Hyunho Yoon Alexa De la Fuente Shumei Source Type: research