Deficiency of Brain ATP-Binding Cassette Transporter A-1 Exacerbates Blood-Brain Barrier and White Matter Damage After Stroke [Basic Sciences]

Conclusions—
We demonstrate that brain ABCA1 deficiency increases BBB leakage, WM/axonal damage, and functional deficits after stroke. Concomitant reduction of insulin-like growth factor 1 and upregulation of matrix metalloproteinase-9 may contribute to brain ABCA1 deficiency–induced BBB and WM/axonal damage in the ischemic brain.

Source: Stroke - February 23, 2015 Category: Neurology Authors: Cui, X., Chopp, M., Zacharek, A., Karasinska, J. M., Cui, Y., Ning, R., Zhang, Y., Wang, Y., Chen, J. Tags: Acute Cerebral Infarction, Behavioral Changes and Stroke Basic Sciences Source Type: research