Cancers, Vol. 13, Pages 3854: Quantitative Assessment and Prognostic Associations of the Immune Landscape in Ovarian Clear Cell Carcinoma
Cancers, Vol. 13, Pages 3854: Quantitative Assessment and Prognostic Associations of the Immune Landscape in Ovarian Clear Cell Carcinoma
Cancers doi: 10.3390/cancers13153854
Authors:
Saira Khalique
Sarah Nash
David Mansfield
Julian Wampfler
Ayoma Attygale
Katherine Vroobel
Harriet Kemp
Richard Buus
Hannah Cottom
Ioannis Roxanis
Thomas Jones
Katharina von Loga
Dipa Begum
Naomi Guppy
Pradeep Ramagiri
Kerry Fenwick
Nik Matthews
Michael J. F. Hubank
Christopher J. Lord
Syed Haider
Alan Melcher
Susana Banerjee
Rachael Natrajan
Ovarian clear cell carcinoma (OCCC) is a rare subtype of epithelial ovarian cancer characterised by a high frequency of loss-of-function ARID1A mutations and a poor response to chemotherapy. Despite their generally low mutational burden, an intratumoural T cell response has been reported in a subset of OCCC, with ARID1A purported to be a biomarker for the response to the immune checkpoint blockade independent of micro-satellite instability (MSI). However, assessment of the different immune cell types and spatial distribution specifically within OCCC patients has not been described to date. Here, we characterised the immune landscape of OCCC by profiling a cohort of 33 microsatellite stable OCCCs at the genomic, gene expression and histological level using targeted sequencing, gene expression profiling using the NanoString targeted immune panel, and multiplex immunofluorescence to assess the spatial distrib...
Source: Cancers - Category: Cancer & Oncology Authors: Saira Khalique Sarah Nash David Mansfield Julian Wampfler Ayoma Attygale Katherine Vroobel Harriet Kemp Richard Buus Hannah Cottom Ioannis Roxanis Thomas Jones Katharina von Loga Dipa Begum Naomi Guppy Pradeep Ramagiri Kerry Fenwick Nik Matthews Michael J Tags: Article Source Type: research
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