Cancers, Vol. 13, Pages 3854: Quantitative Assessment and Prognostic Associations of the Immune Landscape in Ovarian Clear Cell Carcinoma

Cancers, Vol. 13, Pages 3854: Quantitative Assessment and Prognostic Associations of the Immune Landscape in Ovarian Clear Cell Carcinoma Cancers doi: 10.3390/cancers13153854 Authors: Saira Khalique Sarah Nash David Mansfield Julian Wampfler Ayoma Attygale Katherine Vroobel Harriet Kemp Richard Buus Hannah Cottom Ioannis Roxanis Thomas Jones Katharina von Loga Dipa Begum Naomi Guppy Pradeep Ramagiri Kerry Fenwick Nik Matthews Michael J. F. Hubank Christopher J. Lord Syed Haider Alan Melcher Susana Banerjee Rachael Natrajan Ovarian clear cell carcinoma (OCCC) is a rare subtype of epithelial ovarian cancer characterised by a high frequency of loss-of-function ARID1A mutations and a poor response to chemotherapy. Despite their generally low mutational burden, an intratumoural T cell response has been reported in a subset of OCCC, with ARID1A purported to be a biomarker for the response to the immune checkpoint blockade independent of micro-satellite instability (MSI). However, assessment of the different immune cell types and spatial distribution specifically within OCCC patients has not been described to date. Here, we characterised the immune landscape of OCCC by profiling a cohort of 33 microsatellite stable OCCCs at the genomic, gene expression and histological level using targeted sequencing, gene expression profiling using the NanoString targeted immune panel, and multiplex immunofluorescence to assess the spatial distrib...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research