A Novel Time-Activity Information-Sharing Approach Using Nonlinear Mixed Models for Patient-Specific Dosimetry with Reduced Imaging Time Points: Application in SPECT/CT After 177Lu-DOTATATE
Conclusion: Mixed models based on a historical cohort of patients with complete time–activity data and new patients with only 1 or 2 SPECT/CT scans demonstrate less bias on average and significantly fewer outliers when estimating kidney TIA, compared with popular reduced-time-point methods. Use of mixed models allows for reduction of the imaging burden while maintaining accuracy, which is crucial for clinical implementation of dosimetry-based treatment.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Devasia, T. P., Dewaraja, Y. K., Frey, K. A., Wong, K. K., Schipper, M. J. Tags: Clinical (Oncology: GU) Source Type: research
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