Matched-Pair Comparison of 68Ga-PSMA-11 and 18F-rhPSMA-7 PET/CT in Patients with Primary and Biochemical Recurrence of Prostate Cancer: Frequency of Non-Tumor-Related Uptake and Tumor Positivity

Conclusion: The tumor positivity rate was consistently high for 68Ga-PSMA-11 and 18F-rhPSMA-7. Both tracers revealed a considerable number of areas of uptake that were reliably identified as benign by trained physicians making use of corresponding morphologic imaging and known PSMA pitfalls. These were more frequent with 18F-rhPSMA-7. However, the matched-pair comparison could have introduced a source of bias. Adequate reader training can allow physicians to differentiate benign uptake from disease and be able to benefit from the logistical and clinical advantages of 18F-rhPSMA-7.

Source: Journal of Nuclear Medicine - July 30, 2021 Category: Nuclear Medicine Authors: Kroenke, M., Mirzoyan, L., Horn, T., Peeken, J. C., Wurzer, A., Wester, H.-J., Makowski, M., Weber, W. A., Eiber, M., Rauscher, I. Tags: Clinical Investigations Source Type: research