Timing and dosage of FES cycling early after acute spinal cord injury: A case series report
CONCLUSION: Progression of FES cycling in the first 3 months after injury required a highly individualized approach, guided by participant response, rather than standardized increments in stimulation intensity or duration. Changes in muscle CSA did not always correspond with the dose of FES cycling.PMID:34292125 | DOI:10.1080/10790268.2021.1953323
ConclusionsAlthough spinal cord injury is related with high costs, no studies were found with detailed resources use. Also, A variety of instrument were used to examine how different factors have a role in predicting quality of life in spinal cord injury population. However, it is important to consider that differences found in those studies may at least be part in function of the instruments used. Therefore, standardized instruments should be used as part of these process.Key messagesParaplegia or the severity of SCI impact negatively quality of life and positively on healthcare and social costs.Promoting the employment o...
Conditions: Spinal Cord Injuries; Neuropathic Pain Intervention: Procedure: Bilateral anterior cingulotomy Sponsor: St George's, University of London Recruiting
Conclusions: The incidence of sports-related CSI requiring surgery is low with differences in age/sex, sport, and injury patterns. Older males with hyperflexion/axial loading injuries in contact sports were at greatest risk of SCI, complications, and permanent disability. Prevention campaigns, education on proper tackling techniques, and neck strength training are required in sports at high risk of hyperflexion/axial loading injury. Level of Evidence: Level III—retrospective cohort study.
Morphine administration exerts strong analgesic effects against acute pain, but has diminished efficacy against neuropathic pain.1, 8, 23 Rats with peripheral nerve injury, a neuropathic pain model, are less sensitive to the analgesic effects of morphine than normal animals.20 The analgesic effects of opioids are mainly produced by direct post- and pre-synaptic inhibition of nociceptive transmission in the dorsal horn of the spinal cord and activation of the descending inhibitory pathway, including the periaqueductal gray (PAG) and rostral ventromedial medulla (RVM) systems.
Conclusions: Involvement in an environment that was important to the injured person before the accident, in either a passive (in the absence of functional capacity) or active form, promotes a greater sense of self-efficacy and good QoL, regardless of the time that has passed since the accident, and despite high levels of pain or secondary health issues. To fill the gap in professional long-term healthcare services for athletes after SCIs, intervention programs should be considered that support self-efficacy, which is an important factor that can be subject to improvement.
CONCLUSIONS: Resveratrol could promote the function recovery and axonal regeneration, improve histological damage, inhibit apoptosis level after SCI through regulating Wnt/β-catenin signaling pathway. This research expanded the regulatory mechanism of resveratrol in SCI injury.PMID:34647904 | DOI:10.18632/aging.203628
We examined whether punicalagin ameliorates neuropathic pain and inflammatory pain in the spinal cord. Male Sprague –Dawley rats were subjected to chronic constriction injury (CCI) of the sciatic nerve, and an intrathecal catheter was implanted for drug administration. The electronic von Frey test and cold-plate test were performed in CCI rats to evaluate mechanical and cold hyperalgesia in neuropathic pain, an d the formalin test was performed in normal rats to evaluate acute and persistent inflammatory pain. An open-field test was conducted to explore whether punicalagin affects locomotor activity in CCI rats. Puni...
This study provides the first validation of hyperspectral imaging as a tool to differentiate tissues from nerve injured vs non-injured mice. The auto-fluorescent signals associated with nerve injury were not diffuse throughout the tissue but formed specific microscopic size regions. Furthermore, we identified a unique fluorescent signal that could differentiate spinal cord tissue isolated from nerve injured male and female animals. The identification of a specific global autofluorescence fingerprint associated with nerve injury and resultant neuropathic pain opens up the exciting opportunity to develop a diagnostic tool fo...
CONCLUSION: CMI is feasible and acceptable to implement with people with SCI and chronic pain. Further study is warranted to assess potential benefits for pain-related outcomes.PMID:34612802 | DOI:10.1080/10790268.2021.1970894