The Phenotypic/Genotypic Profile of OXA-10-like harboring, Carbapenem-Resistant < em > Pseudomonas aeruginosa < /em > : Using Validated Pharmacokinetic/Pharmacodynamic < em > in vivo < /em > Models to Further Evaluate Enzyme Functionality and Clinical Implications

Antimicrob Agents Chemother. 2021 Jul 26:AAC0127421. doi: 10.1128/AAC.01274-21. Online ahead of print.ABSTRACTIn vitro MICs and in vivo pharmacodynamics of ceftazidime and cefepime human-simulated regimens (HSR) against mCIM-positive P. aeruginosa harboring different OXA-10-like subtypes were described. The murine thigh model assessed ceftazidime (2g q8h HSR) and cefepime (2g and 1g q8h HSR). Phenotypes were similar despite possessing OXA-10-like subtypes with differing spectra. Ceftazidime produced ≥1-log10 kill in all isolates. Cefepime activity was dose-dependent and MIC driven. This approach may be useful in assessing implications of β-lactamase variants.PMID:34310206 | DOI:10.1128/AAC.01274-21
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Source Type: research