Autophagy: A Novel Horizon for Hair Cell Protection

Neural Plast. 2021 Jun 29;2021:5511010. doi: 10.1155/2021/5511010. eCollection 2021.ABSTRACTAs a general sensory disorder, hearing loss was a major concern worldwide. Autophagy is a common cellular reaction to stress that degrades cytoplasmic waste through the lysosome pathway. Autophagy not only plays major roles in maintaining intracellular homeostasis but is also involved in the development and pathogenesis of many diseases. In the auditory system, several studies revealed the link between autophagy and hearing protection. In this review, we aimed to establish the correlation between autophagy and hair cells (HCs) from the aspects of ototoxic drugs, aging, and acoustic trauma and discussed whether autophagy could serve as a potential measure in the protection of HCs.PMID:34306061 | PMC:PMC8263289 | DOI:10.1155/2021/5511010

Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Chang Liu Zhiwei Zheng Pengjun Wang Shuangba He Yingzi He Source Type: research