The response to prolonged fasting in hypothalamic serotonin transporter availability is blunted in obesity

Serotonergic and dopaminergic systems in the brain are essential for homeostatic and reward-associated regulation of food intake and systemic energy metabolism. It is largely unknown how fasting influences these systems or if such effects are altered in humans with obesity. We therefore aimed to evaluate the effects of fasting on hypothalamic/thalamic serotonin transporter (SERT) and striatal dopamine transporter (DAT) availability in lean subjects and subjects with obesity.

Source: Metabolism - Clinical and Experimental - July 28, 2021 Category: Biomedical Science Authors: Katy A. van Galen, Jan Booij, Anouk Schrantee, Sofie M. Adriaanse, Unga A. Unmehopa, Eric Fliers, Gary J. Schwartz, Ralph J. DiLeone, Kasper W. ter Horst, Susanne E. la Fleur, Mireille J. Serlie Source Type: research