FUNDC1 Insufficiency Sensitizes High Fat Diet Intake-Induced Cardiac Remodeling and Contractile Anomaly through ACSL4-Mediated Ferroptosis

Ferroptosis is indicated in cardiovascular diseases. Given the prominent role of mitophagy in the governance of ferroptosis and our recent finding for FUN14 domain containing 1 (FUNDC1) in obesity anomalies, this study evaluated the impact of FUNDC1 deficiency in high fat diet (HFD)-induced cardiac anomalies.

Source: Metabolism - Clinical and Experimental - July 28, 2021 Category: Biomedical Science Authors: Zhaohui Pei, Yandong Liu, Suqin Liu, Wei Jin, Yuanfei Luo, Mingming Sun, Yu Duan, Amir Ajoolabady, James R. Sowers, Yan Fang, Feng Cao, Haixia Xu, Yaguang Bi, Shuyi Wang, Jun Ren Source Type: research