Comparison of oncologic outcomes between patients with Lynch syndrome and sporadic microsatellite instability-high colorectal cancer

CONCLUSION: Our findings indicate that LS CRC is associated with poorer outcomes compared to sporadic CRC with MSI-H, presenting distinct clinical features. In view of the current lack of knowledge on genetic and molecular mechanisms, appropriate management taking into consideration the difficulty of identification of CRC with hypermutable tumors harboring heterogeneity is essential.PMID:34235112 | PMC:PMC8255576 | DOI:10.4174/astr.2021.101.1.13

Source: Annals of Surgical Treatment and Research - July 8, 2021 Category: Surgery Authors: Il Tae Son Duck-Woo Kim Min Hyun Kim Young-Kyoung Shin Ja-Lok Ku Heung-Kwon Oh Sung-Bum Kang Seung-Yong Jeong Kyu Joo Park Source Type: research