Ultrastructural and Immunohistochemical Diagnosis of a Neonatal Herpes Simplex Virus Infection Presenting as Fulminant Hepatitis: A Case Report

We report a male neonate suspected with a metabolic/mitochondrial disease and multi-organ involvement but who developed a fulminant hepatic failure and disseminated coagulopathy secondary to HSV type 1 (HSV-1) infection. The postmortem diagnosis was performed demonstrating HSV-1 in liver tissue by transmission electron microscopy and by retrospective detection of HSV specific antigens by immunohistochemistry.PMID:34302289 | DOI:10.1007/5584_2021_659

Source: Advances in Experimental Medicine and Biology - July 24, 2021 Category: Research Authors: Valentina Papa Nunzio Cosimo Maria Salfi Roberta Costa Ilaria Bettocchi Emilia Ricci Duccio Maria Cordelli Francesca Locatelli Fabio Caramelli Giovanna Cenacchi Source Type: research