Fatty acid modified-antimicrobial peptide analogues with potent antimicrobial activity and topical therapeutic efficacy against Staphylococcus hyicus

This study provides evidence that conjugation of a fatty acid to antimicrobial peptides can improve the activity and have potential for topical therapeutic of S. hyicus skin infections. KEY POINTS: • Lin-Lfcin4NH2/Lfcin5NH2 showed stronger antimicrobial activity than parent peptides. • Lin-Lfcin4NH2/Lfcin5NH2 had a more effective ability to destroy bacterial membranes. • Lin-Lfcin4NH2/Lfcin5NH2 showed a topically higher efficacy than parent peptides.PMID:34319418 | DOI:10.1007/s00253-021-11454-0

Source: Applied Microbiology and Biotechnology - July 28, 2021 Category: Microbiology Authors: He Liu Na Yang Da Teng Ruoyu Mao Ya Hao Xuanxuan Ma Xiumin Wang Jianhua Wang Source Type: research