Natural multi-target modulators of pathological pathways in Alzheimer's disease isolated from the < em > Rhinella arenarum < /em > skin

Nat Prod Res. 2021 Jul 27:1-5. doi: 10.1080/14786419.2021.1953022. Online ahead of print.ABSTRACTThe skin of anuran amphibians is a rich source of compounds with great medicinal potential. Alzheimer's disease (AD) is a complex disease associated with numerous pathological pathways, making their simultaneous modulation necessary. Nowadays the development of anti-AD drugs is focused on a Multi-Target Directed Ligands strategy. Herein we report the bioactivity of the skin extracts of the toad Rhinella arenarum obtained by an invasive and non-invasive methods, against five AD pathological targets (AChE, BChE, MAO-B, antioxidant and chelating activities). The extract derived from the non-invasive technique showed the highest biological activity, being capable of acting on all or almost all the pathological targets of AD, while also avoiding harm to the animal.PMID:34311633 | DOI:10.1080/14786419.2021.1953022
Source: Natural Product Research - Category: Biochemistry Authors: Source Type: research