Genes, Vol. 12, Pages 1149: The Genomic Architecture of Bladder Exstrophy Epispadias Complex
Genes, Vol. 12, Pages 1149: The Genomic Architecture of Bladder Exstrophy Epispadias Complex
Genes doi: 10.3390/genes12081149
Authors:
Glenda M. Beaman
Raimondo M. Cervellione
David Keene
Heiko Reutter
William G. Newman
The bladder exstrophy–epispadias complex (BEEC) is an abdominal midline malformation comprising a spectrum of congenital genitourinary abnormalities of the abdominal wall, pelvis, urinary tract, genitalia, anus, and spine. The vast majority of BEEC cases are classified as non-syndromic and the etiology of this malformation is still unknown. This review presents the current knowledge on this multifactorial disorder, including phenotypic and anatomical characterization, epidemiology, proposed developmental mechanisms, existing animal models, and implicated genetic and environmental components.
Source: Genes - Category: Genetics & Stem Cells Authors: Glenda M. Beaman Raimondo M. Cervellione David Keene Heiko Reutter William G. Newman Tags: Review Source Type: research