' Staggering' Increase in Global Dementia Cases Predicted by 2050'Staggering' Increase in Global Dementia Cases Predicted by 2050

Increased access to education around the world may help drive down dementia cases, but the gains could be wiped out by increases in smoking, obesity, and diabetes, experts say.Medscape Medical News
Source: Medscape FamilyMedicine Headlines - Category: Primary Care Tags: Psychiatry News Source Type: news

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CONCLUSION: Beyond excess deaths alone, the COVID-19 pandemic imposed a greater life expectancy burden on persons aged 25 to 64 years, including those with average or above-average life expectancies, and a disproportionate burden on Black and Hispanic communities.PRIMARY FUNDING SOURCE: National Institute on Aging.PMID:34543588 | DOI:10.7326/M21-2239
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Source Type: research
In this study, mature DCs (mDCs), generated from the GM-CSF and IL-4 induced bone marrow cells, were intravenously injected into wild-type mice. Three days later, assays showed that the mDCs were indeed able to return to the thymus. Homing DCs have been mainly reported to deplete thymocytes and induce tolerance. However, medullary TECs (mTECs) play a crucial role in inducing immune tolerance. Thus, we evaluated whether the mDCs homing into the thymus led to TECs depletion. We cocultured mDCs with mTEC1 cells and found that the mDCs induced the apoptosis and inhibited the proliferation of mTEC1 cells. These effects were onl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
World Psychiatry. 2021 Oct;20(3):417-436. doi: 10.1002/wps.20894.ABSTRACTDecades of research have revealed numerous risk factors for mental disorders beyond genetics, but their consistency and magnitude remain uncer-tain. We conducted a "meta-umbrella" systematic synthesis of umbrella reviews, which are systematic reviews of meta-analyses of individual studies, by searching international databases from inception to January 1, 2021. We included umbrella reviews on non-purely genetic risk or protective factors for any ICD/DSM mental disorders, applying an established classification of the credibility of the evidenc...
Source: World Psychiatry - Category: Psychiatry Authors: Source Type: research
Large survey involving two million adults found links between road and rail traffic and Alzheimer ’s in particularExposure to noise from road traffic and railways is associated with an increased risk of dementia, according to the largest study of its kind.Research has consistently linked transport noise to health conditions including heart disease, diabetes and obesity, but studies on transport noise and dementia were scarce and small, and findings inconsistent.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Dementia Alzheimer's Mental health Road transport Europe Health policy Research publishing Science Denmark Transport policy UK news Source Type: news
In conclusion, patients over 90 years of age had an overall low prevalence of fractures and relative preservation of bone health, suggesting a preserved bone molecular profile in these individuals. Epigenetic factors and activity levels might also have favorably affected bone health. The low percentage of osteoporosis and fractures likely reduced the morbidity and mortality in this population, potentially contributing to their overall longevity. Building a Therapy for Aging Based on SIRT6 Upregulation https://www.fightaging.org/archives/2021/08/building-a-therapy-for-aging-based-on-sirt6-upregulation/ Ge...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsTo prevent DKA, it is important to provide social support for elderly patients with T1DM DKA and lifestyle intervention for younger T2DM or obese patients. Vomiting and serum potassium levels contribute to the classification of diabetes type and subsequent initial treatment in the emergency room.
Source: Diabetology International - Category: Endocrinology Source Type: research
CONCLUSIONS: The ILI did not result in preserved cognitive function or slower rates of cognitive decline in this cohort of individuals who had T2D and were overweight or obese at baseline.PMID:34412057 | DOI:10.1159/000517160
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Authors: Source Type: research
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