Cerebral Small Vessel Disease in Sporadic and Familial Alzheimer Disease

Alzheimer ’s disease is the most common cause of dementia. Biological definitions of AD are limited to the cerebral burden of amyloid β plaques, neurofibrillary pathology and neurodegeneration. However, current evidence suggests various features of small vessel disease (SVD) are part and parcel of and cove rtly modify both sporadic and familial AD. Neuroimaging studies suggest white matter hyperintensities (WMH) explained by vascular mechanisms occur frequently in the AD spectrum. Recent advances have further emphasised that frontal periventricular and posterior WMH are associated with cerebral amyloi d angiopathy (CAA) in familial AD.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Review Source Type: research