B-po01-052 atrial-specific lkb1 knockdown represents a novel mouse model of atrial cardiomyopathy with spontaneous atrial fibrillation

AF is one of the most common cardiac arrhythmias, with> 37 MM patients worldwide. To develop more effective therapies for AF, it is essential to comprehend its underlying mechanisms using better models. Large animal models are more similar to humans, but their availability and cost are big drawbacks. Mice can be genetically manipulated and offer affordable phenotyping platforms. Liver kinase b1 (Lkb1) knockout mice develop spontaneous AF by 8 weeks of age. One of the main limitations of this model, however, is that they also develop ventricular dysfunction and heart failure, complicating the understanding of mechanisms because of the confounding effects of ventricular dysfunction on AF.

Source: Heart Rhythm - July 28, 2021 Category: Cardiology Authors: Mohit Hulsurkar, Satadru Lahiri, Oliver Moore, Lucia Moreira, Issam Abu-Taha, Dobromir Dobrev, Svetlana Reilly, Stanley Nattel, Xander H.T. Wehrens Source Type: research