In vivo induction of CYP in mice by carbamazepine is independent on PXR.

CONCLUSIONS: These data suggest that in vivo induction of CYP in mice by multiple administration of CBZ is independent of PXR. Knowledge of the featured CYP induction profile in mice helps us understand species related CYP induction profiles among rodents and humans resulting from administration of CBZ.
PMID: 25712654 [PubMed - in process]

Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Liu A, Wang C, Hehir M, Zhou T, Yang J Tags: Pharmacol Rep Source Type: research