Mediational Pathways From Genetic Risk to Alcohol Use Disorder in Swedish Men and Women

CONCLUSIONS: Our models concurred in showing that the strongest mediational pathway for genetic risk to AUD includes externalizing symptoms and disorders, which in turn predict further key downstream risk factors. Pathways through lower EA and IPP had smaller effects. IPP had mixed effects (partly predisposing and partly protective) on downstream risk factors. The largest sex difference was a stronger externalizing pathway to genetic risk to AUD in males than in females.PMID:34100712
Source: Journal of Studies on Alcohol and Drugs - Category: Addiction Authors: Source Type: research