Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype

We examined insomnia symptoms and neuropsychological performance 3.4 years later in 511 dementia-free Framingham Heart Study participants (62.65 ± 8.7 years, 50.9% male). Additionally, we explored insomnia symptoms combined with self-reported short habitual sleep duration and effect modification by apolipoprotein E (APOE) ε4 allele status.RESULTS: More severe insomnia symptoms were associated with lower performance on global cognition, and immediate and delayed Logical Memory recall, especially when insomnia symptoms were combined with short sleep duration. The association between insomnia symptoms and poorer memory recall was more pronounced in APOE ε4 allele carriers.DISCUSSION: Insomnia symptom severity was associated with worse subsequent global cognitive and memory performance, which was especially apparent in APOE ε4 allele carriers, suggesting that poor sleep might be particularly detrimental when the brain is already vulnerable to neurodegeneration.PMID:34310026 | DOI:10.1002/alz.12405

Source: The Journal of Alzheimers Association - July 26, 2021 Category: Psychiatry Authors: Andr ée-Ann Baril Alexa S Beiser Erlan Sanchez Vincent Mysliwiec Susan Redline Daniel J Gottlieb George T O'Connor Mitzi M Gonzales Dibya Himali Sudha Seshadri Jayandra J Himali Matthew P Pase Source Type: research