Role of Unfolded Protein Response and Endoplasmic Reticulum-Associated Degradation by Repeated Exposure to Inhalation Anesthetics in < em > Caenorhabditis elegans < /em >

Conclusion: Repeated isoflurane exposure caused significant ER stress in C. elegans. Following the increase in UPR, the ERAD pathway was disrupted by repeated isoflurane exposure and ubiquitinated proteins was accumulated subsequently. UPR and ERAD pathways are potential modifiable neuroprotection targets against anesthesia-induced neurotoxicity.PMID:34220315 | PMC:PMC8241789 | DOI:10.7150/ijms.58043
Source: International Journal of Medical Sciences - Category: Biomedical Science Authors: Source Type: research