Molecules, Vol. 26, Pages 4520: Vitamin E Can Ameliorate Oxidative Damage of Ovine Hepatocytes In Vitro by Regulating Genes Expression Associated with Apoptosis and Pyroptosis, but Not Ferroptosis

Conclusions: oxidative stress induced by hydrogen peroxide caused cellular damage and death in sheep hepatocytes. Pretreatment with vitamin E effectively reduced intracellular ROS levels and protected the hepatocytes from cell death by regulating gene expression associated with apoptosis (RIPK1, TLR7, CASP8, and CASP8AP2) and pyroptosis (NLRP3, IL-1β, and IRAK2), but not ferroptosis (TFRC and PTGS2).

Source: Molecules - July 27, 2021 Category: Chemistry Authors: Luyang Jian Ying Xue Yuefeng Gao Bo Wang Yanghua Qu Shuanghong Li Heqiong Li Zhen Li Bing Wang Hailing Luo Tags: Article Source Type: research