The pros and cons of motor, memory, and emotion-related behavioral tests in the mouse traumatic brain injury model

Discussion covers the apparatus, the test steps, the evaluation indexes, data collection and analysis, animal performance and applications, advantages and disadvantages as well as precautions to eliminate bias wherever possible. We discussed recent studies on TBI-related preconditioning, biomarkers, and optimized behavioral protocols. The neuropsychologic tests employed in clinics were correlated with those used in mouse TBI models. In summary, this review provides a comprehensive, up-to-date reference for TBI researchers to choose the right neurobehavioral protocol according to the research objectives of their translational investigation.PMID:34308784 | DOI:10.1080/01616412.2021.1956290
Source: Neurological Research - Category: Neurology Authors: Source Type: research