Emerging Role of the Gut Microbiome in Irritable Bowel Syndrome

This article describes the evidence from epidemiologic and clinical observational studies highlighting the link between IBS and gut microbiome by investigating postinfection IBS, small intestinal bacterial overgrowth, and microbial dysbiosis. It highlights the effects of gut microbiota on mechanisms implicated in the pathophysiology of IBS, including gut-brain axis, visceral hypersensitivity, motility, epithelial barrier, and immune activation. In addition, it summarizes the current evidence on microbiome-guided therapies in IBS, including probiotics, antibiotics, diet, and fecal microbiota transplant.PMID:34304786 | DOI:10.1016/j.gtc.2021.03.003
Source: The Medical Clinics of North America - Category: General Medicine Authors: Source Type: research