AHA News: Severe Sleep Apnea Could Damage Key Blood Vessels

MONDAY, July 26, 2021 (American Heart Association News) -- Severe sleep apnea is associated with major changes in key arteries and could speed up vascular aging, according to new research. The study published Monday in the Journal of the American...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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This study is one of the first to perform sleep–wake staging on capacitively-coupled respiratory signals in suspected OSA patients and to detect high risk OSA patients based on ccBioZ. The technology and the proposed framework could be applied in multi-night follow-up of OSA patients.
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Mol Med Rep. 2021 Nov;24(5):824. doi: 10.3892/mmr.2021.12464. Epub 2021 Sep 24.ABSTRACTSpontaneous intracerebral hemorrhage (ICH) is a subtype of stroke associated with high mortality and morbidity due to the lack of effective therapy. Obstructive sleep apnea (OSA) has been reported to aggravate early brain injury (EBI) and worsen the overall outcome of patients with ICH. However, the precise role of OSA‑mediated neuroinflammation and apoptosis following ICH has not been confirmed. The present study aimed to investigate the neuronal damage induced by OSA and the potential molecular mechanisms by which ICH‑induced EBI r...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
This study found that pulmonary fibrosis in BLM + IH treated mice was more severe than that in BLM + IA group at day 8 and 21, but not observed at day 4. Besides, the expression of reactive oxygen species (ROS) and hypoxia inducible factor-1α (HIF-1α),which are related to hypoxia reduced oxidative stress and inflammation, were higher in BLM + IH treated mice than BLM + IA mice, and IH increased these indexes in BLM treated mice from day 4 to day 21. Interestingly, a positive linear correlation between the HIF-1α expression and hydroxyproline (HYP) content was observed. We further found some inflammatory c...
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Source Type: research
co García-Río David Gozal Obstructive sleep apnea (OSA) is associated with increased cutaneous melanoma incidence and adverse outcomes. Exosomes are secreted by most cells, and play a role in OSA-associated tumor progression and metastasis. We aimed to study the effects of plasma exosomes from OSA patients before and after adherent treatment with continuous positive airway pressure (CPAP) on melanoma cells lines, and also to identify exosomal miRNAs from melanoma cells exposed to intermittent hypoxia (IH) or normoxia. Plasma-derived exosomes were isolated from moderate-to-severe OSA patients before (V1)...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionOur study results demonstrate that OSAS patients have higher leptin levels in serum/plasma compared to controls, and the serum/plasma leptin level is positively correlated with AHI, especially in adults.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
ConclusionPD individuals are more likely to experience EDS and fall asleep inappropriately during activities if DQB1*0602 positive. Genetic vulnerability may explain EDS risk in PD.
Source: Journal of Neurology - Category: Neurology Source Type: research
Cryosa, a medical device startup developing therapies for obstructive sleep apnea (OSA), announced Thursday it raised $21.5 million in a Series B funding found. The Arden Hills-based company is working on a minimally invasive therapy for OSA that doesn't require daily patient compliance. The round was led by Chattanooga, Tennessee-based Solas BioVentures, with additional funding from Santé Ventures and Tokyo-based HOYA Corp. Cryosa said it will use the funding to continue its human clinical…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
This study investigates the feasibility of estimating the severity of sleep apnea, as quantified by the apnea/hypopnea index (AHI), using the estimated tidal volume and snoring sounds extracted from tracheal signals. Tracheal signals were recorded simultaneously with polysomnography (PSG). The tidal volume was estimated from tracheal signals. The reductions in the tidal volume were detected as potential respiratory events. Additionally, features related to snoring sounds, which quantified variability, temporal clusters, and dominant frequency of snores, were extracted. A step-wise regression model and a greedy search algor...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Source Type: research
The objective of the study was to develop a multiparametric oximetry indicator (IMp-SpO2) to diagnose obstructive sleep apnea in adults.MATERIAL AND METHOD: This was an observational, retrospective study of diagnostic accuracy. We included adults who had had a diagnostic polysomnography with few artifacts and a total sleep time of at least 180 min in the sleep laboratory. Obstructive sleep apnea (OSA) was defined as an apnea-hypopnea index (AHI) ≥ 5. The database was randomly divided into an experimental (Exp-G) and validation (Val-G) group. The program calculated several parameters of oxygen saturation variability (Par...
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Source Type: research
This study investigates the feasibility of estimating the severity of sleep apnea, as quantified by the apnea/hypopnea index (AHI), using the estimated tidal volume and snoring sounds extracted from tracheal signals. Tracheal signals were recorded simultaneously with polysomnography (PSG). The tidal volume was estimated from tracheal signals. The reductions in the tidal volume were detected as potential respiratory events. Additionally, features related to snoring sounds, which quantified variability, temporal clusters, and dominant frequency of snores, were extracted. A step-wise regression model and a greedy search algor...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Source Type: research
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