A vision of immuno-oncology: the Siena think tank of the Italian network for tumor biotherapy (NIBIT) foundation
CONCLUSION: Novel immunotherapies are needed in cancer patients with resistance to or relapse after current immunotherapeutic drugs. Such new treatments may include targeted agents or monoclonal antibodies to overcome the immune-suppressive tumor microenvironment. The mode of combining the novel treatments, including vaccines, needs to be matched to the patient's immune status for achieving the maximum benefit. In this scenario, specific attention should be also paid nowadays to the immune intersection between COVID-19 and cancer.PMID:34301276 | DOI:10.1186/s13046-021-02023-4
Series Type : Expression profiling by RT-PCROrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
ConclusionIpatasertib exhibited rapid absorption and was dose-proportional over a broad dose range. Ipatasertib appeared to be a moderate CYP3A inhibitor when administered at 600 mg and could be administered with or without food in clinical studies.Trail registrationNCT01090960 (registered March 23, 2010); NCT02536391 (registered August 31, 2015).
ConclusionOur study did not demonstrate a protective role of vitamin E in decreasing the incidence of CIPN in patients receiving taxane-based chemotherapy. However, the recovery from CIPN was much better as compared to the control arm, which may indicate a role for vitamin E in decreasing the duration and severity of CIPN.
A judge in California has ruled that state prison guards who work in and around facilities’ health care settings must be vaccinated against the coronavirus
As of the first week of October, 16 participants in the placebo group had gotten a symptomatic, lab-confirmed COVID-19 infection compared with just three who caught COVID in the vaccinated group.
Rep. Glenn Thompson has tested positive for Covid-19, according to a statement released on Twitter, and is being treated at Walter Reed...
Rep. Glenn Thompson, R-Pa., has tested positive for the coronavirus and is currently receiving treatment at a hospital.
The Pfizer vaccine for kids ages 5-11 is 10 micrograms, roughly one third of the dose given to adolescents and adults.WebMD Health News