Safety and Efficacy of a DNA Oligonucleotide Therapy in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma

PNT2258 is a liposomal formulation that encapsulates multiple copies of PNT100, a native, chemically unmodified, 24-base DNA oligonucleotide designed to target the regulatory region upstream of the B-cell lymphoma 2 (BCL2) gene.

Source: Clinical Lymphoma, Myeloma and Leukemia - July 25, 2021 Category: Hematology Authors: Jason Westin, Michael B Maris, Caron A Jacobson, Prapti Patel, Nehal Lakhani, Wael Harb, Dipti Patel-Donnelly, Kelly McCaul, Carolina Escobar, Barbara Klencke, Ayad M. Al-Katib Source Type: research