Integrating systematic pharmacology-based strategy and experimental validation to explore the synergistic pharmacological mechanisms of Guanxin V in treating ventricular remodeling

CONCLUSION: GXV could relieve and reverse VR through anti-apoptosis and anti-fibrosis effects predicted by systematic pharmacology and validated by molecular docking and molecular experiments. Our study deepens the understanding of the molecular mechanisms of GXV in treating VR.PMID:34303037 | DOI:10.1016/j.bioorg.2021.105187
Source: Bioorganic Chemistry - Category: Chemistry Authors: Source Type: research