Transplantation of Pluripotent Stem Cell-Derived Cardiomyocytes into a Myocardial Infarction Model of Cynomolgus Monkey

Methods Mol Biol. 2021;2320:295-302. doi: 10.1007/978-1-0716-1484-6_25.ABSTRACTRecent evidence has provided exciting proof of concepts for the use of pluripotent stem cell-derived cardiomyocytes (PSC-CMs) for cardiac repair; however, large animal studies, which better reflect human disease, are required for clinical application. Here, we describe how to create myocardial infarction in cynomolgus monkey followed by transplantation of PSC-CMs. This method ensures the establishment of a myocardial infarction model and enables reliable PSC-CM transplantation.PMID:34302666 | DOI:10.1007/978-1-0716-1484-6_25
Source: Mol Biol Cell - Category: Molecular Biology Authors: Source Type: research