Anti ‐GQ1b antibody: Recent topics

AbstractResearches on antibodies against glycolipids, mainly gangliosides, have advanced the understanding of the pathophysiology of Guillain-Barr é syndrome. Glycolipid antibody research began with the study of isolated ganglioside antigens and further expanded that area with the discovery of antibodies against complex antigens of two glycolipids. In Fisher syndrome-related disorders, IgG anti-GQ1b antibody is detected at a high rate, but 10 –30% of the cases are antibody-negative. Recently, an antibody that requires Ca2+ to react with ganglioside GQ1b (Ca2+-dependent GQ1b antibody) was discovered in the antibody-negative cases. Ca2+ interacts with the disialosyl group [NeuAc( α2-8)NeuAc(α2-)] of GQ1b, and the antibody is thought to recognize the structure to which Ca2+ is bound. Anti-GQ1b antibody is considered to be more involved in Fisher syndrome-related disorders than was previously shown.
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: REVIEW ARTICLE Source Type: research