Cancers, Vol. 13, Pages 3729: The Human Fetal and Adult Stem Cell Secretome Can Exert Cardioprotective Paracrine Effects against Cardiotoxicity and Oxidative Stress from Cancer Treatment

Cancers, Vol. 13, Pages 3729: The Human Fetal and Adult Stem Cell Secretome Can Exert Cardioprotective Paracrine Effects against Cardiotoxicity and Oxidative Stress from Cancer Treatment Cancers doi: 10.3390/cancers13153729 Authors: Federico Villa Silvia Bruno Ambra Costa Mingchuan Li Michele Russo James Cimino Paola Altieri Clarissa Ruggeri Cansu Gorgun Pierangela De Biasio Dario Paladini Domenico Coviello Rodolfo Quarto Pietro Ameri Alessandra Ghigo Silvia Ravera Roberta Tasso Sveva Bollini Cardiovascular side effects are major shortcomings of cancer treatments causing cardiotoxicity and late-onset cardiomyopathy. While doxorubicin (Dox) has been reported as an effective chemotherapy agent, unspecific impairment in cardiomyocyte mitochondria activity has been documented. We demonstrated that the human fetal amniotic fluid-stem cell (hAFS) secretome, namely the secreted paracrine factors within the hAFS-conditioned medium (hAFS-CM), exerts pro-survival effects on Dox-exposed cardiomyocytes. Here, we provide a detailed comparison of the cardioprotective potential of hAFS-CM over the secretome of mesenchymal stromal cells from adipose tissue (hMSC-CM). hAFS and hMSC were preconditioned under hypoxia to enrich their secretome. The cardioprotective effects of hAFS/hMSC-CM were evaluated on murine neonatal ventricular cardiomyocytes (mNVCM) and on their fibroblast counterpart (mNVFib), and their long-term paracrine effects were investigat...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research