Theoretical Performance of Nonlinear Mixed-Effect Models Incorporating Saliva as an Alternative Sampling Matrix for Therapeutic Drug Monitoring in Pediatrics: A Simulation Study

Conclusions: Saliva as an alternative matrix for noninvasive TDM is possible using nonlinear mixed-effect models combined with Bayesian optimization. This article provides a workflow to explore TDM performance for compounds measured in saliva and can be used for evaluation during model building.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Dr. Roger Jelliffe Memorial Issue: Focus on Personalized Dosing Strategies Source Type: research