Tacrolimus Bayesian Dose Adjustment in Pediatric Renal Transplant Recipients

Background: Immunosuppressant Bayesian Dose Adjustment (ISBA) is an online expert system that estimates the area under the curve (AUC) of immunosuppressive drugs through pharmacokinetic modelling and Bayesian estimation to propose dose adjustments to reach predefined exposure targets. The ISBA database was retrospectively analyzed to describe tacrolimus pharmacokinetics and exposure, evaluate the efficiency of ISBA dose recommendations, and propose tacrolimus AUC0–12h target ranges for pediatric renal allograft recipients treated with immediate release tacrolimus. Methods: The database included 1935 tacrolimus dose adjustment requests from 419 patients
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Dr. Roger Jelliffe Memorial Issue: Focus on Personalized Dosing Strategies Source Type: research