Covid-19 and Risk of Venous Thromboembolism in Ethnically Diverse Populations

Chest. 2021 Jul 19:S0012-3692(21)01353-2. doi: 10.1016/j.chest.2021.07.025. Online ahead of print.ABSTRACTBACKGROUND: Limited existing data suggest the novel coronavirus disease 2019 (Covid-19) may increase risk for venous thromboembolism (VTE) but information from large, ethnically diverse populations with appropriate controls are lacking.RESEARCH QUESTION: Does the rate of VTE among adults hospitalized with Covid-19 differ from matched hospitalized controls without Covid-19?STUDY DESIGN AND METHODS: We conducted a retrospective study among hospitalized adults with laboratory-confirmed Covid-19 and hospitalized adults without evidence of Covid-19 matched on age, gender, race/ethnicity, acute illness severity, and month of hospitalization between February-August 2020 from two integrated healthcare delivery systems with 36 hospitals. Outcomes included VTE (deep venous thrombosis or pulmonary embolism ascertained using diagnosis codes combined with validated natural language processing algorithms applied to electronic health records) and death from any cause at 30 days. Fine and Gray hazards regression was performed to evaluate the association of Covid-19 with VTE after accounting for competing risk of death and residual differences between groups, as well as identifying predictors of VTE in patients with Covid-19.RESULTS: We identified 6,319 adults with Covid-19 and 6,319 matched adults without Covid-19, with mean (SD) age of 60.0 (17.2) years, 46% women, 53.1% Hispanic, 14.6%...
Source: Chest - Category: Respiratory Medicine Authors: Source Type: research