Predicting in vivo escape dynamics of HIV-1 from a broadly neutralizing antibody [Evolution]

Broadly neutralizing antibodies are promising candidates for treatment and prevention of HIV-1 infections. Such antibodies can temporarily suppress viral load in infected individuals; however, the virus often rebounds by escape mutants that have evolved resistance. In this paper, we map a fitness model of HIV-1 interacting with broadly neutralizing antibodies...

Source: Proceedings of the National Academy of Sciences - July 23, 2021 Category: Science Authors: Matthiȷs Meiȷers, Kanika Vanshylla, Henning Gruell, Florian Klein, Michael Lassig Tags: Evolution Biological Sciences Source Type: research