Notch-Jagged signaling complex defined by an interaction mosaic [Biochemistry]

The Notch signaling system links cellular fate to that of its neighbors, driving proliferation, apoptosis, and cell differentiation in metazoans, whereas dysfunction leads to debilitating developmental disorders and cancers. Other than a five-by-five domain complex, it is unclear how the 40 extracellular domains of the Notch1 receptor collectively engage the...

Source: Proceedings of the National Academy of Sciences - July 23, 2021 Category: Science Authors: Matthieu R. Zeronian, Oleg Klykov, Julia Portell i de Montserrat, Maria J. Koniȷnenberg, Anamika Gaur, Richard A. Scheltema, Bert J. C. Janssen Tags: Biochemistry Biological Sciences Source Type: research