Structural basis for ligand binding modes of CTP synthase [Biochemistry]

Cytidine triphosphate synthase (CTPS), which comprises an ammonia ligase domain and a glutamine amidotransferase domain, catalyzes the final step of de novo CTP biosynthesis. The activity of CTPS is regulated by the binding of four nucleotides and glutamine. While glutamine serves as an ammonia donor for the ATP-dependent conversion of...

Source: Proceedings of the National Academy of Sciences - July 23, 2021 Category: Science Authors: Xian Zhou, Chen-Jun Guo, Chia-Chun Chang, Jiale Zhong, Huan-Huan Hu, Guang-Ming Lu, Ji-Long Liu Tags: Biochemistry Biological Sciences Source Type: research