Arrest of WNT/{beta}-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries [Developmental Biology]

Germ cells form the basis for sexual reproduction by producing gametes. In ovaries, primordial germ cells exit the cell cycle and the pluripotency-associated state, differentiate into oogonia, and initiate meiosis. Despite the importance of germ cell differentiation for sexual reproduction, signaling pathways regulating their fate remain largely unknown. Here, we...

Source: Proceedings of the National Academy of Sciences - July 23, 2021 Category: Science Authors: Morgane Le Rolle, Filippo Massa, Pam Siggers, Laurent Turchi, Agnes Loubat, Bon–Kyoung Koo, Hans Clevers, Andy Greenfield, Andreas Schedl, Marie–Christine Chaboissier, Anne–Amandine Chassot Tags: Developmental Biology Biological Sciences Source Type: research