Methadone Destabilizes Cardiac Repolarization during Sleep

This study demonstrates that chronic methadone use is associated with increased cardiac repolarization instability. Methadone's pro-arrhythmic impact may be mediated by sleep-related hypoxemia which could explain the increased nocturnal mortality associated with this opioid.PMID:34287835 | DOI:10.1002/cpt.2368

Source: Clinical Pharmacology and Therapeutics - July 21, 2021 Category: Drugs & Pharmacology Authors: Soroosh Solhjoo Naresh M Punjabi Andrada E Ivanescu Ciprian Crainiceanu Irina Gaynanova Cassie Wicken Chester Buckenmaier Mark C Haigney Source Type: research