Multiple endocrine neoplasia

Multiple endocrine neoplasia (MEN) describes the occurrence of tumours affecting two or more endocrine glands in one individual. Two main forms are recognized: type 1 (MEN1) and type 2 (MEN2). MEN1 is characterized by the combined occurrence of parathyroid, pituitary and pancreatic neuroendocrine tumours, whereas MEN2 features medullary thyroid cancer in association with phaeochromocytoma and parathyroid tumours. Although both MEN1 and MEN2 are autosomal dominant disorders, they have contrasting molecular aetiologies: MEN1 results from inactivating germline mutations of the MEN1 tumour suppressor gene, whereas MEN2 results from activating mutations in the RET proto-oncogene.

Source: Medicine - July 23, 2021 Category: Internal Medicine Authors: Paul J. Newey Tags: Endocrine cancer Source Type: research