TNF-{alpha} down-regulates sarcoplasmic reticulum Ca2+ ATPase expression and leads to left ventricular diastolic dysfunction through binding of NF-{kappa}B to promoter response element

Conclusions
TNF-α suppresses SERCA2a gene expression via the IKK/IB/NF-B pathway and binding of NF-B to the SERCA2a gene promoter, and its effect is blocked by simvastatin, demonstrating the potential therapeutic effect of statins in treating inflammation-related diastolic dysfunction.

Source: Cardiovascular Research - February 23, 2015 Category: Cardiology Authors: Tsai, C.-T., Wu, C.-K., Lee, J.-K., Chang, S.-N., Kuo, Y.-M., Wang, Y.-C., Lai, L.-P., Chiang, F.-T., Hwang, J.-J., Lin, J.-L. Tags: Cardiac biology and remodelling Source Type: research