Cardiomyocyte-specific expression of CYP2J2 prevents development of cardiac remodelling induced by angiotensin II

Conclusion
Cardiomyocyte-specific expression of CYP2J2 or treatment with EETs protects against cardiac remodelling by attenuating oxidative stress-mediated NF-Bp65 nuclear translocation via PPAR- activation.

Source: Cardiovascular Research - February 23, 2015 Category: Cardiology Authors: He, Z., Zhang, X., Chen, C., Wen, Z., Hoopes, S. L., Zeldin, D. C., Wang, D. W. Tags: Cardiac biology and remodelling Source Type: research