The Aryl Hydrocarbon Receptor-Dependent TGF-{alpha}/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis
Conclusions
The AHR-dependent TGF-α/VEGF-B ratio is altered in a subtype, severity, and disease activity–specific manner and correlates with time to conversion from CIS to MS. It may thus represent a novel marker and serve as additive guideline for immunomodulatory strategies in MS.
Classification of Evidence
This study provides Class III evidence that serum levels of AHR, TGF-α, and VEGF-B distinguish subtypes of MS and predict the severity and disease activity of MS.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Cirac, A., Tsaktanis, T., Beyer, T., Linnerbauer, M., Andlauer, T., Grummel, V., Nirschl, L., Loesslein, L., Quintana, F. J., Hemmer, B., Rothhammer, V. Tags: All Immunology, Autoimmune diseases, Class III, Multiple sclerosis Article Source Type: research
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