The Aryl Hydrocarbon Receptor-Dependent TGF-{alpha}/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis

Conclusions The AHR-dependent TGF-α/VEGF-B ratio is altered in a subtype, severity, and disease activity–specific manner and correlates with time to conversion from CIS to MS. It may thus represent a novel marker and serve as additive guideline for immunomodulatory strategies in MS. Classification of Evidence This study provides Class III evidence that serum levels of AHR, TGF-α, and VEGF-B distinguish subtypes of MS and predict the severity and disease activity of MS.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: All Immunology, Autoimmune diseases, Class III, Multiple sclerosis Article Source Type: research